Ocellatuspyrones A‒G, new antibacterial polypropionates from the Chinese mollusk Placobranchus ocellatus
نویسندگان
چکیده
Abstract Marine invertebrates serve as rich sources of secondary metabolites with intriguing chemical diversities and a wide spectrum biological activities. Particularly, marine shell-less sacoglossan mollusks have attracted much attentions due to the fact that apply complex defense agents against their predators. With purpose discovering bioactive develop marine-derived medicines from South China Sea, we conducted study on photosynthetic mollusk Placobranchus ocellatus. As result, seven new γ -pyrone polypropionates, namely ( ±)-ocellatuspyrone A 1 ), B 2 ocellatuspyrones C−G 5 , 9 − 12 along five known been isolated characterized Sea ocellatus . Extensive spectroscopic analysis, single crystal X-ray diffraction modified Mosher’s method, ECD comparison, CD exciton chirality TDDFT-ECD calculation, conversion were used determine structures absolute configurations compounds stereochemistry undefined 4 6 7 All these polypropionates evaluated in bioassays for activities, including antibacterial, neuroprotective effect, anti-inflammatory, PTP1B inhibitory, antiviral Compounds 8 11 found first time show antibacterial activity fish pathogenic bacteria Streptococcus parauberis (the main pathogen causing streptococcal infections acute death) MIC values 35.8, 34.2, 37.4 μg/mL, respectively, which might be potential novel treatment infectious diseases.
منابع مشابه
New Chitosan/Ag/Carbacylamidophosphate nanocomposites: Preparation and antibacterial study
Two new Chitosan-based nanocomposite films were prepared: Chitosan /7% Ag nanoparticles (NPs) (NC1) and Chitosan/7% Ag NPs/5%Carbacylamidophosphate(NC2), in which the carbacylamidophosphate derivitive is N-Nicotinyl-N′,N″- bis(hexamethylenyl) phosphorictriamide (NHE) with the formula: C5H4NC(O)NHP(O)(NC6H12)2. X-ray Powder Diffraction (XRD), Field Emission Scanning Electron Microscopy (FE-SEM) ...
متن کاملAntibacterial biodegradable Mg-Ag alloys.
The use of magnesium alloys as degradable metals for biomedical applications is a topic of ongoing research and the demand for multifunctional materials is increasing. Hence, binary Mg-Ag alloys were designed as implant materials to combine the favourable properties of magnesium with the well-known antibacterial property of silver. In this study, three Mg-Ag alloys, Mg2Ag, Mg4Ag and Mg6Ag that ...
متن کاملAntibacterial burst-release from minimal Ag-containing plasma polymer coatings.
Biomaterials releasing silver (Ag) are of interest because of their ability to inhibit pathogenic bacteria including antibiotic-resistant strains. In order to investigate the potential of nanometre-thick Ag polymer (Ag/amino-hydrocarbon) nanocomposite plasma coatings, we studied a comprehensive range of factors such as the plasma deposition process and Ag cation release as well as the antibacte...
متن کاملExiguapyrone and exiguaone, new polypropionates from the Mediterranean cephalaspidean mollusc Haminoea exigua
متن کامل
Antibacterial effect assessment of ZnS: Ag nanoparticles
Objective(s): A large ratio of surface to volume of nanoparticles in comparison with bulk ones, will increase the cell penetration and therefore their toxicity. Materials and Methods: Chemical precipitation method was used in order to synthesis of ZnS:Ag quantum dots. Their Physical properties and characteristics were assessed by X-ray diffraction, Ultra Violet-Visible Spectrophotometer, Transm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Marine Life Science & Technology
سال: 2023
ISSN: ['2096-6490', '2662-1746']
DOI: https://doi.org/10.1007/s42995-023-00179-w